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Registro Completo |
Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
Data corrente: |
09/02/2023 |
Data da última atualização: |
10/02/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
AFONSO, J.; SHIM, W. J.; BODEN, M.; FORTES, M. R. S.; DINIZ, W. J. da S.; LIMA, A. O. de; ROCHA, M. I. P.; CARDOSO, T. F.; BRUSCADIN, J. J.; GROMBONI, C. F.; NOGUEIRA, A. R. A.; MOURÃO, G. B.; ZERLOTINI NETO, A.; COUTINHO, L. L.; REGITANO, L. C. de A. |
Afiliação: |
JULIANA AFONSO; WOO JUN SHIM, THE UNIVERSITY OF QUEENSLAND; MIKAEL BODEN, THE UNIVERSITY OF QUEENSLAND; MARINA RUFINO SALINAS FORTES, THE UNIVERSITY OF QUEENSLAND; WELLISON JARLES DA SILVA DINIZ, AUBURN UNIVERSITY; ANDRESSA OLIVEIRA DE LIMA, UNIVERSITY OF WASHINGTON; MARINA IBELLI PEREIRA ROCHA, UNIVERSIDADE FEDERAL DE SÃO CARLOS; TAINÃ FIGUEIREDO CARDOSO; JENNIFER JESSICA BRUSCADIN, UNIVERSIDADE FEDERAL DE SÃO CARLOS; CAIO FERNANDO GROMBONI, INSTITUTO FEDERAL DE EDUCAÇÃO, CIÊNCIA E TECNOLOGIA DA BAHIA; ANA RITA ARAUJO NOGUEIRA; GERSON BARRETO MOURÃO, UNIVERSIDADE DE SÃO PAULO; ADHEMAR ZERLOTINI NETO, CNPTIA; LUIZ LEHMANN COUTINHO, UNIVERSIDADE DE SÃO PAULO; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
Título: |
Repressive epigenetic mechanisms, such as the H3K27me3 histone modification, were predicted to affect muscle gene expression and its mineral content in Nelore cattle. |
Ano de publicação: |
2023 |
Fonte/Imprenta: |
Biochemistry and Biophysics Reports, v. 33, 101420, Mar. 2023. |
DOI: |
https://doi.org/10.1016/j.bbrep.2023.101420 |
Idioma: |
Inglês |
Conteúdo: |
Abstract. Epigenetic repression has been linked to the regulation of different cell states. In this study, we focus on the influence of this repression, mainly by H3K27me3, over gene expression in muscle cells, which may affect mineral content, a phenotype that is relevant to muscle function and beef quality. Based on the inverse relationship between H3K27me3 and gene expression (i.e., epigenetic repression) and on contrasting sample groups, we computationally predicted regulatory genes that affect muscle mineral content. To this end, we applied the TRIAGE predictive method followed by a rank product analysis. This methodology can predict regulatory genes that might be affected by repressive epigenetic regulation related to mineral concentration. Annotation of orthologous genes, between human and bovine, enabled our investigation of gene expression in the Longissimus thoracis muscle of Bos indicus cattle. The animals under study had a contrasting mineral content in their muscle cells. We identified candidate regulatory genes influenced by repressive epigenetic mechanisms, linking histone modification to mineral content in beef samples. The discovered candidate genes take part in multiple biological pathways, i.e., impulse transmission, cell signalling, immunological, and developmental pathways. Some of these genes were previously associated with mineral content or regulatory mechanisms. Our findings indicate that epigenetic repression can partially explain the gene expression profiles observed in muscle samples with contrasting mineral content through the candidate regulators here identified. MenosAbstract. Epigenetic repression has been linked to the regulation of different cell states. In this study, we focus on the influence of this repression, mainly by H3K27me3, over gene expression in muscle cells, which may affect mineral content, a phenotype that is relevant to muscle function and beef quality. Based on the inverse relationship between H3K27me3 and gene expression (i.e., epigenetic repression) and on contrasting sample groups, we computationally predicted regulatory genes that affect muscle mineral content. To this end, we applied the TRIAGE predictive method followed by a rank product analysis. This methodology can predict regulatory genes that might be affected by repressive epigenetic regulation related to mineral concentration. Annotation of orthologous genes, between human and bovine, enabled our investigation of gene expression in the Longissimus thoracis muscle of Bos indicus cattle. The animals under study had a contrasting mineral content in their muscle cells. We identified candidate regulatory genes influenced by repressive epigenetic mechanisms, linking histone modification to mineral content in beef samples. The discovered candidate genes take part in multiple biological pathways, i.e., impulse transmission, cell signalling, immunological, and developmental pathways. Some of these genes were previously associated with mineral content or regulatory mechanisms. Our findings indicate that epigenetic repression can partially explain the gene expressio... Mostrar Tudo |
Palavras-Chave: |
Epigenetic regulation; Expressão gênica; Gene repression; H3K27me3. |
Thesagro: |
Bos Indicus; Gado de Corte; Gado Nelore; Mineral. |
Thesaurus Nal: |
Epigenetics; Gene expression; Minerals. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1151623/1/AP-Repressive-epigenetic-2023.pdf
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Marc: |
LEADER 02933naa a2200433 a 4500 001 2151623 005 2023-02-10 008 2023 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1016/j.bbrep.2023.101420$2DOI 100 1 $aAFONSO, J. 245 $aRepressive epigenetic mechanisms, such as the H3K27me3 histone modification, were predicted to affect muscle gene expression and its mineral content in Nelore cattle.$h[electronic resource] 260 $c2023 520 $aAbstract. Epigenetic repression has been linked to the regulation of different cell states. In this study, we focus on the influence of this repression, mainly by H3K27me3, over gene expression in muscle cells, which may affect mineral content, a phenotype that is relevant to muscle function and beef quality. Based on the inverse relationship between H3K27me3 and gene expression (i.e., epigenetic repression) and on contrasting sample groups, we computationally predicted regulatory genes that affect muscle mineral content. To this end, we applied the TRIAGE predictive method followed by a rank product analysis. This methodology can predict regulatory genes that might be affected by repressive epigenetic regulation related to mineral concentration. Annotation of orthologous genes, between human and bovine, enabled our investigation of gene expression in the Longissimus thoracis muscle of Bos indicus cattle. The animals under study had a contrasting mineral content in their muscle cells. We identified candidate regulatory genes influenced by repressive epigenetic mechanisms, linking histone modification to mineral content in beef samples. The discovered candidate genes take part in multiple biological pathways, i.e., impulse transmission, cell signalling, immunological, and developmental pathways. Some of these genes were previously associated with mineral content or regulatory mechanisms. Our findings indicate that epigenetic repression can partially explain the gene expression profiles observed in muscle samples with contrasting mineral content through the candidate regulators here identified. 650 $aEpigenetics 650 $aGene expression 650 $aMinerals 650 $aBos Indicus 650 $aGado de Corte 650 $aGado Nelore 650 $aMineral 653 $aEpigenetic regulation 653 $aExpressão gênica 653 $aGene repression 653 $aH3K27me3 700 1 $aSHIM, W. J. 700 1 $aBODEN, M. 700 1 $aFORTES, M. R. S. 700 1 $aDINIZ, W. J. da S. 700 1 $aLIMA, A. O. de 700 1 $aROCHA, M. I. P. 700 1 $aCARDOSO, T. F. 700 1 $aBRUSCADIN, J. J. 700 1 $aGROMBONI, C. F. 700 1 $aNOGUEIRA, A. R. A. 700 1 $aMOURÃO, G. B. 700 1 $aZERLOTINI NETO, A. 700 1 $aCOUTINHO, L. L. 700 1 $aREGITANO, L. C. de A. 773 $tBiochemistry and Biophysics Reports$gv. 33, 101420, Mar. 2023.
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Embrapa Agricultura Digital (CNPTIA) |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
Data corrente: |
30/09/2004 |
Data da última atualização: |
29/08/2023 |
Tipo da produção científica: |
Artigo em Anais de Congresso |
Autoria: |
VASCONCELOS, V. R. de; BARROS, N. N.; WANDER, A. E.; ARAÚJO, M. R. de. |
Afiliação: |
VÂNIA RODRIGUES DE VASCONCELOS, UNIVERSIDADE FEDERAL DO PIAUI; NELSON NOGUEIRA BARROS, CNPC; ALCIDO ELENOR WANDER, CNPC; MARCELO RENATO DE ARAÚJO, CNPC. |
Título: |
Efeito bioeconômico de níveis de concentrado para cordeiros em confinamento. |
Ano de publicação: |
2004 |
Fonte/Imprenta: |
In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 41., 2004, Campo Grande, MS. A produção animal e a segurança alimentar: anais dos simpósios e dos resumos. Campo Grande, MS: Sociedade Brasileira de Zootecnia: Embrapa Gado de Corte, 2004. 5 f. CD-ROM. |
Idioma: |
Português |
Palavras-Chave: |
Brasil; Cross-breeding; Economic viability; Piauí; Semi-árido; Viabilidade econômica. |
Thesagro: |
Alimento Concentrado; Análise Econômica; Confinamento; Cordeiro; Cruzamento Animal; Ganho de Peso; Ovino. |
Thesaurus NAL: |
Body weight; Feed concentrates; Feed supplements; Sheep; Weight gain. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/48581/1/AAC-Efeito-bioeconomico.pdf
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Marc: |
LEADER 01194nam a2200349 a 4500 001 1530752 005 2023-08-29 008 2004 bl uuuu u00u1 u #d 100 1 $aVASCONCELOS, V. R. de 245 $aEfeito bioeconômico de níveis de concentrado para cordeiros em confinamento.$h[electronic resource] 260 $aIn: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 41., 2004, Campo Grande, MS. A produção animal e a segurança alimentar: anais dos simpósios e dos resumos. Campo Grande, MS: Sociedade Brasileira de Zootecnia: Embrapa Gado de Corte, 2004. 5 f. CD-ROM.$c2004 650 $aBody weight 650 $aFeed concentrates 650 $aFeed supplements 650 $aSheep 650 $aWeight gain 650 $aAlimento Concentrado 650 $aAnálise Econômica 650 $aConfinamento 650 $aCordeiro 650 $aCruzamento Animal 650 $aGanho de Peso 650 $aOvino 653 $aBrasil 653 $aCross-breeding 653 $aEconomic viability 653 $aPiauí 653 $aSemi-árido 653 $aViabilidade econômica 700 1 $aBARROS, N. N. 700 1 $aWANDER, A. E. 700 1 $aARAÚJO, M. R. de
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